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Perhaps by providing an alternative coping strategy regular physical activity has been shown to effectively prevent and treat stress-related disorders including anxiety Manger and Motta,depression Babyak et al. Furthermore, although alcohol abuse and dependence, anxiety disorders, and major depressive disorder are highly comorbid cf: Hettema et al. Studying connections between alcohol and exercise may yield new insights into common neural pathways activated by alcohol, exercise, and stress, as well as those underlying the interplay of stress-related disorders.

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Regions of the mesocorticolimbic system that are activated by drugs of abuse are also activated by wheel running Rhodes et al. Moreover, long-term repeated voluntary wheel running produces plastic changes in the reward circuitry Greenwood et al.

Considerable data also suggest that wheel running has antidepressant effects, including stimulation of hippocampal neurogenesis Crews et al. Running may also reduce anxiety-related behaviors in mice Salam et al. Several studies have investigated the effects of wheel running on voluntary alcohol consumption in rodents.

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